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KMID : 0617320030120010245
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Journal of Pharmacetical Sceiences Ewha Womans University
2003 Volume.12 No. 1 p.245 ~ p.247
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Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3´,4´-Tetrahydrofuran Ring
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Chun, Moon Woo
Kim, Myong Jung/Kim, Hea Ok/Moon, Hyung Ryong/Kim, Hee-Doo/Kim, Joong Hyup/Jeong, Lak Shin
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Abstract
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Pyrimidine nucleosides fused with 3´,4´-tetrahydrofuran ring were synthesized, starting from l,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities. Thymine analogue I and its corresponding 2´-deoxy analogue 3 exhibited high cytotoxicity instead of giving antiviral activities.
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